Fibroids can shrink for any number of reasons. Herbal and other supplements, like enzymes, are touted as shrinking fibroids because one woman's fibroids shrank while she took the supplement. Some women have shrunk their fibroids with prayer. Many women find relief from using various supplements. One study showed that about 20% of the women incidentally in the study had fibroid shrinkage with no apparent cause for the shrinkage.